Beta
Aminophylline
medication Under reviewA bronchodilator medication used to treat respiratory conditions such as asthma, chronic bronchitis, and emphysema.
Research summary
Research in healthy human volunteers shows that aminophylline reliably increases ventilation, tidal volume, and ventilatory responsiveness to carbon dioxide, and can enhance the performance of fatigued respiratory muscles, particularly the diaphragm. Several small randomized or crossover studies in normal subjects demonstrate improvements in diaphragmatic contractility after induced fatigue and increased neural drive to inspiratory muscles, while therapeutic doses have minimal effect on contractility of a fresh, non-fatigued diaphragm. These same studies document dose-related activation of the sympathetic nervous system, with increases in catecholamines, heart rate, blood pressure, and metabolic markers, as well as a propensity for cardiac arrhythmias at clinically relevant concentrations. The overall research consensus is that aminophylline is effective as a bronchodilator and respiratory stimulant but carries a significant risk profile, making it unsuitable as a performance or wellness supplement for healthy individuals outside controlled medical settings.
Reported Benefits
No reports yet
Be the first to report this effect and help the community.
Add Aminophylline to your stack to report effects
Aminophylline and respiratory muscle interaction in normal humans.
Aliverti A, Dellacà RL, Pelosi P, et al.
Both salbutamol and aminophylline increase ventilatory response to carbon dioxide in normal subjects
Malo JL, Cartier A, L'Archevêque J, et al.
Aminophylline increases respiratory muscle activity during hypercapnia in humans.
Suzuki S, Sato M, Kohno S, et al.
No reports yet
Be the first to report this effect and help the community.
Add Aminophylline to your stack to report effects
Aminophylline improves diaphragmatic contractility in normal subjects
Loring SH, Mead J, Wanger JS, et al.
Aminophylline increases respiratory muscle activity during hypercapnia in humans.
Suzuki S, Sato M, Kohno S, et al.
Reported Side Effects
No reports yet
Be the first to report this effect and help the community.
Add Aminophylline to your stack to report effects
Effect of intravenous aminophylline on plasma levels of catecholamines and related cardiovascular and metabolic responses in man.
Stolk J, ten Have H, Verhoeff N, et al.
Both salbutamol and aminophylline increase ventilatory response to carbon dioxide in normal subjects
Malo JL, Cartier A, L'Archevêque J, et al.
No reports yet
Be the first to report this effect and help the community.
Add Aminophylline to your stack to report effects
Effect of intravenous aminophylline on plasma levels of catecholamines and related cardiovascular and metabolic responses in man.
Stolk J, ten Have H, Verhoeff N, et al.
Both salbutamol and aminophylline increase ventilatory response to carbon dioxide in normal subjects
Malo JL, Cartier A, L'Archevêque J, et al.
No reports yet
Be the first to report this effect and help the community.
Add Aminophylline to your stack to report effects
Aminophylline increases respiratory muscle activity during hypercapnia in humans.
Suzuki S, Sato M, Kohno S, et al.
Aminophylline improves diaphragmatic contractility in normal subjects
Loring SH, Mead J, Wanger JS, et al.
No reports yet
Be the first to report this effect and help the community.
Add Aminophylline to your stack to report effects
Effect of intravenous aminophylline on plasma levels of catecholamines and related cardiovascular and metabolic responses in man.
Stolk J, ten Have H, Verhoeff N, et al.
Research (5 studies)
Aminophylline increases respiratory muscle activity during hypercapnia in humans.
Suzuki S, Sato M, Kohno S, et al.
Aminophylline and respiratory muscle interaction in normal humans.
Aliverti A, Dellacà RL, Pelosi P, et al.
Both salbutamol and aminophylline increase ventilatory response to carbon dioxide in normal subjects
Malo JL, Cartier A, L'Archevêque J, et al.
Effect of intravenous aminophylline on plasma levels of catecholamines and related cardiovascular and metabolic responses in man.
Stolk J, ten Have H, Verhoeff N, et al.
Aminophylline improves diaphragmatic contractility in normal subjects
Loring SH, Mead J, Wanger JS, et al.
Community updates
No updates yet for this supplement.
Be the first to share your experience!