Research Hub

Nature Portfolio’s supplement research page highlights a preclinical/clinical signal that nicotinamide may help restore NAD+ in heart failure with preserved ejection fraction, and notes potassium-enriched salt reduced stroke and cardiovascular events in SSaSS.

The supplied search results do not contain 4-5 peer-reviewed supplement studies from the last 30 days. The most recent directly relevant item is a 2026 NIH/PubMed report on rising U.S. supplement use, but it is not a clinical efficacy finding.

A nationally representative trend analysis found overall dietary supplement use increased from 51.8% in 2011-2012 to 61.4% in 2021-2023, with larger use of multiple products and specific supplements like vitamin D, zinc, and probiotics.

NIH-funded analysis reported that dietary supplement use was not associated with lower death risk overall, while adequate intake of some nutrients was beneficial when obtained from food rather than supplements.

A nationwide cohort study found no association between ever using dietary supplements and mortality outcomes. Benefits from adequate vitamin A, vitamin K, magnesium, and zinc intake were confined to foods, not supplements.

An analysis of 63,442 adults showed declining multivitamin/multimineral use over 25 years while targeted supplements for immunity, gut, skin, and joint health have increased, especially since around 2010.

The REDUCE-IT trial found that 4 g/day of highly purified EPA ethyl ester added to statin therapy cut major cardiovascular events by about 25% in patients with high triglycerides and cardiovascular disease or diabetes.

A global overview reported increased use of vitamin C, vitamin D, zinc, omega-3s, probiotics, and selenium during the COVID-19 pandemic, mainly for perceived immune support and infection risk reduction.

A large NHANES analysis found US adult supplement use rose from 51.8% to 61.4% between 2011–2012 and 2021–2023, with more people using multiple products and sharp growth in vitamin D, zinc, probiotics, fiber, and ginger.

New data identify a niacin-derived metabolite that promotes vascular inflammation in preclinical models and is associated with increased major adverse cardiovascular events in humans, suggesting high-dose niacin supplements may raise CVD risk.

Recent research links NAD+ deficiency to heart failure with preserved ejection fraction and suggests that restoring NAD+ levels with nicotinamide supplementation may improve diastolic function.

A study of 63,442 US adults over 25 years finds declining multivitamin use and rising uptake of specialized supplements marketed for immunity, gut, skin, and joint health, especially among older adults.

NHANES analysis shows US adult supplement use increased from 51.8% to 61.4% between 2011–2012 and 2021–2023, with notable growth in use of vitamin D, zinc, probiotics, fiber, and other targeted products.

Within non-multivitamin supplements, vitamin D and zinc had the greatest rise in use among US adults, with additional increases in vitamin K, biotin, B12, magnesium, and other minerals, particularly after 2009–2014.[5]

The US Preventive Services Task Force concluded there is inadequate evidence that commonly used vitamin, mineral, and multivitamin supplements prevent heart disease, stroke, or cancer, and specifically advises against beta-carotene due to increased lung cancer risk in smokers and asbestos-exposed workers.[7]

Analysis of NHANES 2007–2018 data found that 53% of the US population aged ≥1 year used at least one dietary supplement daily, predominantly micronutrient products, with higher use in women, older adults, and non-Hispanic whites.[6]

A global overview of dietary supplements reports marked increases in use of vitamins C and D and zinc during the COVID-19 pandemic, as these were among the most commonly chosen products to boost immunity and reduce perceived infection risk.[4]

A JAMA Network Open analysis of 63,442 US adults from 1999–2023 shows overall supplement use rose to 60%, with use shifting away from multivitamins toward targeted products for immunity, inflammation, gut, skin, and joint health, especially in older adults.[5]

A JAMA Network Open analysis of 63,442 US adults (1999–2023) found overall supplement use rose to 61.4%, with multivitamin use declining and growth in targeted products like fiber, probiotics, and immunity/gut health supplements.[5]

A recent research news report highlights that US adults increasingly choose niche supplements for immunity, inflammation, gut, skin, and joint health, while multivitamin use has fallen, especially among younger and middle-aged adults.[6]

An updated USPSTF recommendation states there is inadequate evidence that common vitamin, mineral, or multivitamin supplements prevent cardiovascular disease, stroke, or cancer, and specifically advises against beta-carotene due to increased lung cancer risk in smokers.[8]

A global regulatory review reports increased use of vitamin C, vitamin D, zinc, omega-3s, probiotics, and selenium during the COVID-19 pandemic, mainly to boost immunity and reduce perceived infection risk.[4]

A Nature Portfolio report says excess niacin produces a metabolite that promotes vascular inflammation in preclinical models and is associated with higher major adverse cardiovascular event rates in humans.