Beta
Blood pressure medications
medication Under reviewLorundrostat is an investigational oral medication designed as an add-on therapy for individuals with uncontrolled high blood pressure despite standard treatments. It targets aldosterone synthase, an enzyme involved in producing aldosterone, a hormone that regulates blood pressure by influencing sodium and fluid balance in the kidneys. By inhibiting this enzyme, lorundrostat reduces aldosterone levels, leading to decreased sodium retention, lower fluid volume, and ultimately reduced blood pressure.
Research summary
Clinical trials demonstrate that lorundrostat effectively lowers systolic blood pressure in patients with treatment-resistant hypertension when added to existing medications. Phase 2 and 3 studies show significant reductions compared to placebo, with good tolerability in diverse populations. Ongoing research continues to evaluate long-term safety and efficacy across broader patient groups.
Reported Benefits
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Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension
Michael Wilkinson et al.
Advance-HTN Phase 2 Study of Lorundrostat
Luke Laffin et al.
New Drug Shows Promise for Stubbornly High Blood Pressure
Harvard Health Publishing
Baxdrostat for uncontrolled and resistant hypertension: rationale and design of the Phase 3 clinical trials BaxHTN, BaxAsia, and Bax24.
Bryan Williams et al.
No reports yet
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Add Blood pressure medications to your stack to report effects
Baxdrostat for uncontrolled and resistant hypertension: rationale and design of the Phase 3 clinical trials BaxHTN, BaxAsia, and Bax24.
Bryan Williams et al.
ACCOMPLISH Trial: Comparison of Fixed-Dose Combinations
Not specified
No side effects tracked yet
No side effects have been reported by studies or users for this habit yet.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Hypertension — elevated blood pressure requiring management
Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension
Michael Wilkinson et al.
Advance-HTN Phase 2 Study of Lorundrostat
Luke Laffin et al.
Baxdrostat for uncontrolled and resistant hypertension: rationale and design of the Phase 3 clinical trials BaxHTN, BaxAsia, and Bax24.
Bryan Williams et al.
New Drug Shows Promise for Stubbornly High Blood Pressure
Harvard Health Publishing
ACCOMPLISH Trial: Comparison of Fixed-Dose Combinations
Not specified
Research (5 studies)
Advance-HTN Phase 2 Study of Lorundrostat
Luke Laffin et al.
Baxdrostat for uncontrolled and resistant hypertension: rationale and design of the Phase 3 clinical trials BaxHTN, BaxAsia, and Bax24.
Bryan Williams et al.
Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension
Michael Wilkinson et al.
New Drug Shows Promise for Stubbornly High Blood Pressure
Harvard Health Publishing
ACCOMPLISH Trial: Comparison of Fixed-Dose Combinations
Not specified
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