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Chemotherapy agents
medication Under reviewChemotherapy agents are pharmaceutical drugs designed to target rapidly dividing cells, primarily used to treat cancer by interfering with cell division processes such as DNA replication and repair. They work through various mechanisms, including alkylating DNA, inhibiting topoisomerase enzymes, or disrupting microtubule function, which halts cancer cell proliferation. While effective against tumors, these agents lack specificity and can impact healthy dividing cells like those in blood, hair follicles, and the gastrointestinal tract. In healthy individuals, exposure to chemotherapy agents occurs mainly in clinical research settings for pharmacokinetic, safety, and drug interaction studies, particularly with non-cytotoxic targeted therapies like kinase inhibitors. These studies help establish dosing and safety profiles before patient trials. General health applications are limited, as routine use in healthy people is not recommended due to risks, but research explores minimizing genetic damage and side effects for safer oncology development.
Research summary
Scientific evidence from healthy human subjects is primarily derived from phase 1 clinical trials using healthy volunteers to assess pharmacokinetics, safety, and tolerability of oncology drugs, especially non-cytotoxic small molecules like tyrosine kinase inhibitors. These studies confirm that certain agents produce measurable genetic mutations, premature aging in blood cells, and side effects such as skin reactions, gastrointestinal issues, and hepatotoxicity, though mitigation strategies exist. Consensus supports their use in healthy volunteers for accelerating drug development when direct DNA damage is absent, but highlights the need for caution with traditional cytotoxic agents.
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How Healthy Volunteer Studies can Accelerate Oncology Drug Development
Celerion Team
Healthy volunteers in first‐in‐human oncology drug development for small molecules: a systematic review of published trials
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How Healthy Volunteer Studies can Accelerate Oncology Drug Development
Celerion Team
No reports yet
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How Healthy Volunteer Studies can Accelerate Oncology Drug Development
Celerion Team
Research (2 studies)
How Healthy Volunteer Studies can Accelerate Oncology Drug Development
Celerion Team
Healthy volunteers in first‐in‐human oncology drug development for small molecules: a systematic review of published trials
Not specified in excerpt
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