Doseloop Beta

Clomipramine

medication Under review

A tricyclic antidepressant medication used to treat obsessive-compulsive disorder and other conditions.

Research summary

AI-Generated Content: This summary was created by AI and may contain errors. Always verify with peer-reviewed sources.

The human evidence base for clomipramine is strongest for obsessive-compulsive disorder, where it has long been shown to reduce obsessive and compulsive symptoms and remains a well-established treatment option. Reviews and clinical summaries also describe benefit in some other psychiatric or pain-related conditions, but those uses are generally off-label and less consistently supported. Research and labeling also show that clomipramine can cause clinically important adverse effects, including sedation, anticholinergic effects, weight gain, sexual dysfunction, and cardiovascular or seizure-related risks. Overall, the evidence supports clomipramine as an effective prescription drug for specific indications, but not as a health supplement.

Reported Benefits

Reported Side Effects

Related health conditions

Research showing how this habit affects specific health conditions. Always consult healthcare professionals.

May Help With

Research (5 studies)

Systematic Review

Screening the Combination of Gemcitabine, Clomipramine, and Resveratrol in HL-60 Leukemia Cells.

StatPearls • 2025

Molden E, Spigset O, and colleagues

Systematic Review

Palliative psychiatry and euthanasia in refractory obsessive-compulsive disorder: A case report.

Military Medicine/Clinical review • 2021

Health.mil

Preliminary

Anafranil (clomipramine hydrochloride) prescribing information

FDA Drug Label • 2019

U.S. Food and Drug Administration

RCT

Clomipramine in the treatment of patients with obsessive-compulsive disorder. The Clomipramine Collaborative Study Group.

Acta Psychiatrica Scandinavica • 1991

PubMed record

Systematic Review

Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder.

Drugs • 1990

Bremner JD

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At a glance

Users tracking 0
Linked studies 5
Researched benefits 4
Side effects noted 6