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Conjugated Estrogens
medication Under reviewA mixture of estrogen hormones used to treat vaginal symptoms of menopause such as dryness, burning, and irritation.
Research summary
Scientific evidence from large-scale randomized controlled trials in postmenopausal women without a uterus demonstrates that conjugated estrogens do not increase breast cancer risk and may confer a protective effect in adherent users. Vaginal administration shows improvements in vaginal pH and maturation value without systemic adverse changes. Overall consensus supports its safety profile for breast cancer in specific populations, though broader cardiovascular and bone health benefits are noted in related estrogen therapy research, with mixed findings on other outcomes due to study limitations.
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Effects of vaginal administration of conjugated estrogens tablet on sexual function in postmenopausal women with sexual dysfunction: a double-blind, randomized, placebo-controlled trial.
Sukmawati N, Wiweko B, Tjuatja S, et al.
Breast Cancer After Use of Estrogen Alone in Postmenopausal Women From the Women's Health Initiative: A Sectional Analysis of a Randomized Controlled Trial
Anderson GL, Limacher M, Assaf AR, et al.
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No side effects have been reported by studies or users for this habit yet.
Research (2 studies)
Effects of vaginal administration of conjugated estrogens tablet on sexual function in postmenopausal women with sexual dysfunction: a double-blind, randomized, placebo-controlled trial.
Sukmawati N, Wiweko B, Tjuatja S, et al.
Breast Cancer After Use of Estrogen Alone in Postmenopausal Women From the Women's Health Initiative: A Sectional Analysis of a Randomized Controlled Trial
Anderson GL, Limacher M, Assaf AR, et al.
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