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Dapsone
medication Under reviewA sulfone antibiotic and anti-inflammatory medication used to treat conditions such as leprosy, dermatitis herpetiformis, and acne.
Research summary
Limited evidence from pilot studies in patients with chronic Lyme disease and post-treatment Lyme disease syndrome suggests dapsone combination therapy improves symptoms like fatigue, pain, sleep disturbances, and cognitive issues. No studies were identified specifically involving healthy human subjects, with available data focused on diseased populations or in vitro mechanisms. Consensus indicates potential utility in targeted antimicrobial roles but highlights risks like hemolytic anemia.
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The Use of Dapsone as a Novel “Persister” Drug in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome
Horowitz RI, Freeman PR
Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1
Horowitz RI, Freeman PR
Research (2 studies)
Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1
Horowitz RI, Freeman PR
The Use of Dapsone as a Novel “Persister” Drug in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome
Horowitz RI, Freeman PR
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