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Dextromethorphan
medication Under reviewAn over-the-counter antitussive medication used to temporarily relieve coughs caused by minor throat and bronchial irritation.
Research summary
Dextromethorphan is well-established as an effective cough suppressant at therapeutic doses, with clinical evidence demonstrating its efficacy in reducing cough rates in both adults and children. Recent translational research has identified novel mechanisms of action, particularly its ability to inhibit collagen trafficking and reduce fibrillar collagen deposition, suggesting potential antifibrotic properties for treating pulmonary fibrosis. Early clinical trials are underway to investigate these emerging applications, though most evidence beyond cough suppression remains preliminary or limited to animal and in vitro studies.
Reported Benefits
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Dextromethorphan Emerges as a Novel Antidepressant Pathway for Treatment-Resistant Depression
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Objective and self-reported evidence of dextromethorphan antitussive efficacy in children, aged 6-11 years, with acute cough due to the common cold.
Meeves, S.G., Cruz-Rivera, M., Leyva, R.A., Wilson, B.L., Moreira, S.A., Gelotte, C.K., Jayawardena, S.
Reported Side Effects
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Dextromethorphan - StatPearls
NIH StatPearls Editorial Board
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Dextromethorphan - StatPearls
NIH StatPearls Editorial Board
No reports yet
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Dextromethorphan - StatPearls
NIH StatPearls Editorial Board
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Dextromethorphan - StatPearls
NIH StatPearls Editorial Board
Research (3 studies)
Dextromethorphan Emerges as a Novel Antidepressant Pathway for Treatment-Resistant Depression
Dextromethorphan - StatPearls
NIH StatPearls Editorial Board
Objective and self-reported evidence of dextromethorphan antitussive efficacy in children, aged 6-11 years, with acute cough due to the common cold.
Meeves, S.G., Cruz-Rivera, M., Leyva, R.A., Wilson, B.L., Moreira, S.A., Gelotte, C.K., Jayawardena, S.
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