Beta
Domperidone
medication Under reviewA dopamine antagonist medication used to treat nausea, vomiting, and gastrointestinal motility disorders.
Research summary
Human research on domperidone in otherwise healthy adults has focused mainly on its effects on gastroesophageal motility, gastric emptying, and short‑term safety, as well as its ability to increase prolactin and milk production in postpartum women who are otherwise medically stable. Short studies in healthy volunteers using single or brief dosing schedules show measurable pro‑motility effects on the esophagus and stomach, and generally report good short‑term tolerability in small samples. Randomized controlled trials in mothers of preterm infants with lactation failure show that domperidone can substantially increase daily milk volume over about two weeks, with relatively few short‑term adverse events reported within the study periods. At the same time, broader pharmacoepidemiologic data in general patient populations and high‑risk groups, along with regulatory safety communications, highlight concerns about cardiac arrhythmias and sudden cardiac death, particularly at higher doses, in older adults, or in those with underlying heart disease or other risk factors. A recent randomized trial in otherwise stable outpatients with mild‑to‑moderate COVID‑19 found no antiviral benefit compared with placebo. Overall, the research consensus is that domperidone has clear pharmacologic activity and specific clinical uses but is not a general‑health supplement and should be used only under medical supervision, with attention to cardiac risk and drug interactions.
Reported Benefits
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Effect of domperidone on the composition of preterm human breast milk.
Campbell-Yeo ML, Allen AC, Joseph KS, et al.
Enhancing Human Milk Production With Domperidone in Mothers of Preterm Infants.
Grzeskowiak LE, Lim SW, Thomas AE, Ritchie U, Gordon AL
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Effect of domperidone on gastro-oesophageal function in normal human subjects.
Novak F, Kjellén G, Tibbling L
Reported Side Effects
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Effect of 10 mg domperidone on gastric emptying of a high-fat meal and appetite sensations in healthy subjects
Nielsen LS, Buemann B, Toubro S, et al.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Worsen
Progressive loss of kidney function over time
Effect of 10 mg domperidone on gastric emptying of a high-fat meal and appetite sensations in healthy subjects
Nielsen LS, Buemann B, Toubro S, et al.
Research (4 studies)
Enhancing Human Milk Production With Domperidone in Mothers of Preterm Infants.
Grzeskowiak LE, Lim SW, Thomas AE, Ritchie U, Gordon AL
Effect of 10 mg domperidone on gastric emptying of a high-fat meal and appetite sensations in healthy subjects
Nielsen LS, Buemann B, Toubro S, et al.
Effect of domperidone on the composition of preterm human breast milk.
Campbell-Yeo ML, Allen AC, Joseph KS, et al.
Effect of domperidone on gastro-oesophageal function in normal human subjects.
Novak F, Kjellén G, Tibbling L
Community updates
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