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Estropipate
medication Under reviewAn estrogen medication used primarily in menopausal hormone therapy to treat symptoms such as hot flashes and to prevent osteoporosis.
Research summary
Scientific evidence from large-scale trials like the Women's Health Initiative primarily highlights risks rather than benefits in healthy postmenopausal women, including increased stroke, venous thromboembolism, and probable dementia with long-term use. While short-term relief from menopausal symptoms like hot flashes and vaginal atrophy is reported, consensus emphasizes that benefits do not outweigh risks for chronic disease prevention in healthy individuals, with bone loss prevention noted but not restoration to premenopausal levels.
Reported Benefits
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Double-Blind Placebo-Controlled Study of Estropipate on Bone Mass
Not specified
Reported Side Effects
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Conjugated equine estrogen influence on mammographic density in postmenopausal women in a substudy of the women's health initiative randomized trial.
Women's Health Initiative Investigators
Estrogen Plus Progestin and Colorectal Cancer: Long-Term Findings From the Women's Health Initiative Randomized Clinical Trial.
Women's Health Initiative Investigators
No reports yet
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Comparison of PM2.5 Air Pollution Exposures and Health Effects Associations Using 11 Different Modeling Approaches in the Women's Health Initiative Memory Study (WHIMS).
Women's Health Initiative Investigators
Research (4 studies)
Double-Blind Placebo-Controlled Study of Estropipate on Bone Mass
Not specified
Conjugated equine estrogen influence on mammographic density in postmenopausal women in a substudy of the women's health initiative randomized trial.
Women's Health Initiative Investigators
Comparison of PM2.5 Air Pollution Exposures and Health Effects Associations Using 11 Different Modeling Approaches in the Women's Health Initiative Memory Study (WHIMS).
Women's Health Initiative Investigators
Estrogen Plus Progestin and Colorectal Cancer: Long-Term Findings From the Women's Health Initiative Randomized Clinical Trial.
Women's Health Initiative Investigators
Community updates
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