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Flumazenil
medication Under reviewA selective GABA-A receptor antagonist used to reverse the effects of benzodiazepines.
Research summary
Scientific evidence on flumazenil centers on its efficacy and safety as a reversal agent for benzodiazepine-induced sedation and overdose, particularly in controlled clinical environments. Studies in patients receiving benzodiazepines for sedation or experiencing overdose demonstrate rapid awakening and improved respiration, though primarily in intoxicated or medicated individuals rather than baseline healthy subjects. Limited data exist on routine use in healthy humans without benzodiazepine exposure, with consensus affirming its diagnostic utility in coma differentiation but cautioning against risks like seizures in dependent users.
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Flumazenil - StatPearls
Khan A, Sharma S
Pharmacokinetics and clinical use of flumazenil (Ro 15-1788).
Klotz U, Kanto J
Use of flumazenil in the treatment of drug overdose: a double-blind and open clinical study in 110 patients.
Weinbroum A, Rudick V, Sorkine P, Nevo Y, Halpern P, Geller E, Niv D
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Research (3 studies)
Flumazenil - StatPearls
Khan A, Sharma S
Use of flumazenil in the treatment of drug overdose: a double-blind and open clinical study in 110 patients.
Weinbroum A, Rudick V, Sorkine P, Nevo Y, Halpern P, Geller E, Niv D
Pharmacokinetics and clinical use of flumazenil (Ro 15-1788).
Klotz U, Kanto J
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