Beta
Hydrochlorothiazide
medication Under reviewA thiazide-type diuretic medication used to treat high blood pressure and edema by helping the kidneys remove excess fluid and salt.
Research summary
Scientific evidence from clinical trials demonstrates that hydrochlorothiazide effectively reduces blood pressure in patients with hypertension, with comparable cardiovascular outcomes to other diuretics like chlorthalidone in large-scale studies, though it may be slightly less potent. Research consensus supports its role as a safe and well-tolerated agent for blood pressure management, particularly in older adults and specific ethnic groups, but highlights a need for monitoring electrolytes due to potential imbalances. Head-to-head trials show no significant differences in major adverse events, reinforcing its established use despite alternatives being explored for superior potency.
Reported Benefits
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Clinical Studies on Hydrochlorothiazide
Freis et al.
Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies.
Gong et al.
Per-Protocol Analysis of Chlorthalidone Versus Hydrochlorothiazide for Cardiovascular Event Prevention-Diuretic Comparison Project.
Ishak et al.
Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial.
Black et al.
No reports yet
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Add Hydrochlorothiazide to your stack to report effects
Per-Protocol Analysis of Chlorthalidone Versus Hydrochlorothiazide for Cardiovascular Event Prevention-Diuretic Comparison Project.
Ishak et al.
Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial.
Black et al.
No side effects tracked yet
No side effects have been reported by studies or users for this habit yet.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Hypertension — elevated blood pressure requiring management
Per-Protocol Analysis of Chlorthalidone Versus Hydrochlorothiazide for Cardiovascular Event Prevention-Diuretic Comparison Project.
Ishak et al.
Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial.
Black et al.
Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies.
Gong et al.
Clinical Studies on Hydrochlorothiazide
Freis et al.
Research (4 studies)
Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies.
Gong et al.
Per-Protocol Analysis of Chlorthalidone Versus Hydrochlorothiazide for Cardiovascular Event Prevention-Diuretic Comparison Project.
Ishak et al.
Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial.
Black et al.
Clinical Studies on Hydrochlorothiazide
Freis et al.
Community updates
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