Beta
Indinavir
medication Under reviewAn antiretroviral protease inhibitor used as a component of combination therapy to treat HIV/AIDS.
Research summary
Scientific evidence from studies in healthy humans primarily demonstrates that indinavir acutely impairs insulin-stimulated glucose disposal, suggesting a direct blockade of glucose transport without affecting intracellular signaling pathways. This effect occurs rapidly at therapeutic plasma concentrations and mirrors findings from isolated tissue experiments, indicating potential metabolic disruptions even in the absence of HIV infection. Research consensus highlights its tolerability in short-term use among healthy volunteers, though with noted impacts on insulin sensitivity.
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