Iron
supplement Under reviewIron is an essential mineral critical for the formation of hemoglobin, which transports oxygen in the blood, and myoglobin, which stores oxygen in muscles. It plays a key role in energy production, DNA synthesis, and electron transport in cellular respiration. Iron exists in two main dietary forms: heme iron from animal sources, which is more readily absorbed, and non-heme iron from plants and fortified foods, which has lower bioavailability but can be enhanced by vitamin C. Iron works by binding to proteins like transferrin for transport and ferritin for storage, maintaining homeostasis through tight regulation of absorption in the intestines. Deficiency leads to fatigue, reduced cognitive function, and impaired physical performance due to inadequate oxygen delivery, while excess can promote oxidative stress. Supplementation is primarily used to correct deficiencies, supporting recovery of iron stores and hemoglobin levels in scenarios like blood donation or dietary shortfalls.
Research summary
Scientific evidence from randomized controlled trials and systematic reviews shows iron supplementation effectively restores hemoglobin and iron levels in healthy adults after blood donation and improves cognitive domains like attention, concentration, and IQ, particularly in those with low baseline iron status. Benefits are more pronounced in deficient individuals, with consistent effects on attention across iron-replete and anaemic groups, though evidence for broader cognitive improvements requires larger, longer-term studies. Adverse effects in healthy humans are limited, with some reports of gastrointestinal discomfort from high doses, but overall safety is favorable at standard doses. Consensus supports targeted use to prevent deficiency without routine supplementation in iron-sufficient populations due to risks of overload.
Reported Benefits
No reports yet
Be the first to report this effect and help the community.
Add Iron to your stack to report effects
The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis.
Maydani M, et al.
No reports yet
Be the first to report this effect and help the community.
Add Iron to your stack to report effects
The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis.
Maydani M, et al.
Reported Side Effects
No reports yet
Be the first to report this effect and help the community.
Add Iron to your stack to report effects
Iron supplements: the quick fix with long-term consequences.
Agarwal MB
Research (2 studies)
The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis.
Maydani M, et al.
Iron supplements: the quick fix with long-term consequences.
Agarwal MB
Community updates
No updates yet for this supplement.
Be the first to share your experience!