Beta
Memantine
medication Under reviewAn NMDA receptor antagonist often used for cognitive enhancement and neuroprotection.
Research summary
Most human research on memantine has been conducted in patients with Alzheimer’s disease or other dementias, where randomized controlled trials and meta-analyses show modest benefits on cognition and global function, along with a safety profile generally comparable to placebo at therapeutic doses. These data suggest that partial NMDA receptor blockade can produce clinically meaningful effects on cognition and may reduce excitotoxic neuronal injury in vulnerable populations. In contrast, there is very limited controlled research in truly healthy human subjects. Early-phase pharmacokinetic and safety studies in healthy volunteers indicate that memantine is orally bioavailable, crosses the blood–brain barrier, and is generally well tolerated at therapeutic doses, but they do not demonstrate clear cognitive enhancement. Ongoing or planned trials are exploring its use for prevention of Alzheimer’s disease in at‑risk but not yet demented individuals, which may provide more insight into neuroprotective effects in relatively healthy adults. At present, there is no strong human evidence that memantine improves memory, focus, or other cognitive domains in healthy people, and its use in this context remains experimental and off‑label.
Reported Benefits
No reports yet
Be the first to report this effect and help the community.
Add Memantine to your stack to report effects
The use of memantine for prevention of Alzheimer’s disease: a feasibility and safety study in cognitively normal older adults at risk
Manning CA, D'Abreu A, Fansler A, et al.
Pharmacokinetics and tolerability of memantine in healthy volunteers
Periclou A, Ventura D, Rao N, Abramowitz W
Effect of long-term treatment with memantine on mortality in patients with dementia: a meta-analysis
Li L, Wu Z, Ma T, Liu Y
No reports yet
Be the first to report this effect and help the community.
Add Memantine to your stack to report effects
Effect of long-term treatment with memantine on mortality in patients with dementia: a meta-analysis
Li L, Wu Z, Ma T, Liu Y
Reported Side Effects
No reports yet
Be the first to report this effect and help the community.
Add Memantine to your stack to report effects
Phase I evaluation of the safety and tolerability of multiple ascending doses of memantine in healthy young adults
Kornhuber J, Weller M, Schoppmeyer K, Riederer P
A randomized, double-blind, placebo-controlled trial of memantine in healthy volunteers: effects on cognition and subjective perception
Görtelmeyer R, Wollenweber R, Riederer P
Pharmacokinetics and tolerability of memantine in healthy volunteers
Periclou A, Ventura D, Rao N, Abramowitz W
No reports yet
Be the first to report this effect and help the community.
Add Memantine to your stack to report effects
A randomized, double-blind, placebo-controlled trial of memantine in healthy volunteers: effects on cognition and subjective perception
Görtelmeyer R, Wollenweber R, Riederer P
Pharmacokinetics and tolerability of memantine in healthy volunteers
Periclou A, Ventura D, Rao N, Abramowitz W
No reports yet
Be the first to report this effect and help the community.
Add Memantine to your stack to report effects
Memantine pharmacokinetics in subjects with renal impairment and healthy volunteers
Periclou A, Ventura D, Rao N, Abramowitz W
Pharmacokinetics and tolerability of memantine in healthy volunteers
Periclou A, Ventura D, Rao N, Abramowitz W
No reports yet
Be the first to report this effect and help the community.
Add Memantine to your stack to report effects
A randomized, double-blind, placebo-controlled trial of memantine in healthy volunteers: effects on cognition and subjective perception
Görtelmeyer R, Wollenweber R, Riederer P
Phase I evaluation of the safety and tolerability of multiple ascending doses of memantine in healthy young adults
Kornhuber J, Weller M, Schoppmeyer K, Riederer P
No reports yet
Be the first to report this effect and help the community.
Add Memantine to your stack to report effects
Effect of long-term treatment with memantine on mortality in patients with dementia: a meta-analysis
Li L, Wu Z, Ma T, Liu Y
Research (6 studies)
The use of memantine for prevention of Alzheimer’s disease: a feasibility and safety study in cognitively normal older adults at risk
Manning CA, D'Abreu A, Fansler A, et al.
Effect of long-term treatment with memantine on mortality in patients with dementia: a meta-analysis
Li L, Wu Z, Ma T, Liu Y
Pharmacokinetics and tolerability of memantine in healthy volunteers
Periclou A, Ventura D, Rao N, Abramowitz W
Memantine pharmacokinetics in subjects with renal impairment and healthy volunteers
Periclou A, Ventura D, Rao N, Abramowitz W
Phase I evaluation of the safety and tolerability of multiple ascending doses of memantine in healthy young adults
Kornhuber J, Weller M, Schoppmeyer K, Riederer P
A randomized, double-blind, placebo-controlled trial of memantine in healthy volunteers: effects on cognition and subjective perception
Görtelmeyer R, Wollenweber R, Riederer P
Community updates
No updates yet for this supplement.
Be the first to share your experience!