Beta
Mestranol
medication Under reviewA synthetic estrogen medication used primarily as a component in combination oral contraceptives.
Research summary
Mestranol was one of the first estrogens used in oral contraceptive formulations, though it has largely been replaced by ethinylestradiol in modern contraceptive pills due to improved efficacy and lower required dosages. Research demonstrates that mestranol is highly effective at inhibiting ovulation, with approximately 98% effectiveness at dosages of 75-80 micrograms daily. The compound undergoes hepatic metabolism and has a relatively short elimination half-life of 50 minutes in its inactive form, while its active metabolite ethinylestradiol has a half-life of 7 to 36 hours. Historical studies have documented its effects on endometrial tissue and reproductive function in women.
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Mestranol in oral contraceptive formulations and ovulation inhibition studies
Roland et al. (1966) and subsequent researchers
Research (1 study)
Mestranol in oral contraceptive formulations and ovulation inhibition studies
Roland et al. (1966) and subsequent researchers
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