Beta
Methamphetamine
medication Under reviewMethamphetamine is a powerful synthetic central nervous system stimulant, not a dietary supplement. In healthy humans, it produces short-term increases in alertness, wakefulness, confidence, and perceived energy, largely through enhanced catecholamine signaling, especially dopamine and norepinephrine. These effects are accompanied by appetite suppression, faster heart rate, higher blood pressure, and elevated body temperature, which reflect its strong sympathetic activation. Because it is a potent stimulant with a high abuse potential, methamphetamine is not used for general health or wellness purposes. Its pharmacologic effects can briefly improve attention and psychomotor coordination at low doses, but the overall risk profile is substantial and includes dependence, sleep disruption, mood changes, cardiovascular strain, and neuropsychiatric harm.
Research summary
The evidence in healthy humans shows that methamphetamine can acutely increase alertness, energy, and some measures of attention and psychomotor performance, but these are short-lived stimulant effects rather than health benefits. Across human and clinical literature, the same compound is consistently associated with clinically important harms, especially elevated blood pressure, tachycardia, insomnia, anxiety, and appetite suppression. There is no credible research consensus supporting methamphetamine as a health supplement. Available human evidence instead supports its classification as a high-risk stimulant with potential for dependence, cognitive impairment with repeated use, and serious cardiovascular and psychiatric adverse effects.
Reported Benefits
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A review of the clinical pharmacology of methamphetamine.
Cruickshank CC, Dyer KR
Methamphetamine: effects on the brain, gut and immune system
PubMed/Review authors not specified in result
Neuropsychological effects of chronic methamphetamine use on human performance
Hart CL, Marvin CB, Silver R, Smith EE
No reports yet
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Add Methamphetamine to your stack to report effects
A review of the clinical pharmacology of methamphetamine.
Cruickshank CC, Dyer KR
Neuropsychological effects of chronic methamphetamine use on human performance
Hart CL, Marvin CB, Silver R, Smith EE
No reports yet
Be the first to report this effect and help the community.
Add Methamphetamine to your stack to report effects
A review of the clinical pharmacology of methamphetamine.
Cruickshank CC, Dyer KR
Methamphetamine: effects on the brain, gut and immune system
PubMed/Review authors not specified in result
Reported Side Effects
No reports yet
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Methamphetamine - StatPearls
Richards JR, et al.
A review of the clinical pharmacology of methamphetamine.
Cruickshank CC, Dyer KR
Methamphetamine use: a comprehensive review of molecular, biochemical, and physiological effects
Berman SM, et al.
No reports yet
Be the first to report this effect and help the community.
Add Methamphetamine to your stack to report effects
Methamphetamine - StatPearls
Richards JR, et al.
Methamphetamine use: a comprehensive review of molecular, biochemical, and physiological effects
Berman SM, et al.
No reports yet
Be the first to report this effect and help the community.
Add Methamphetamine to your stack to report effects
Methamphetamine - StatPearls
Richards JR, et al.
Methamphetamine use: a comprehensive review of molecular, biochemical, and physiological effects
Berman SM, et al.
No reports yet
Be the first to report this effect and help the community.
Add Methamphetamine to your stack to report effects
A review of the clinical pharmacology of methamphetamine.
Cruickshank CC, Dyer KR
Methamphetamine use: a comprehensive review of molecular, biochemical, and physiological effects
Berman SM, et al.
No reports yet
Be the first to report this effect and help the community.
Add Methamphetamine to your stack to report effects
Methamphetamine - StatPearls
Richards JR, et al.
Methamphetamine use: a comprehensive review of molecular, biochemical, and physiological effects
Berman SM, et al.
No reports yet
Be the first to report this effect and help the community.
Add Methamphetamine to your stack to report effects
Methamphetamine - StatPearls
Richards JR, et al.
A review of the clinical pharmacology of methamphetamine.
Cruickshank CC, Dyer KR
No reports yet
Be the first to report this effect and help the community.
Add Methamphetamine to your stack to report effects
Methamphetamine - StatPearls
Richards JR, et al.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Attention-Deficit/Hyperactivity Disorder affecting focus, impulse control, and executive function
A review of the clinical pharmacology of methamphetamine.
Cruickshank CC, Dyer KR
May Worsen
Major depressive disorder or persistent depressive symptoms
Methamphetamine use: a comprehensive review of molecular, biochemical, and physiological effects
Berman SM, et al.
Methamphetamine: effects on the brain, gut and immune system
PubMed/Review authors not specified in result
Difficulty falling asleep, staying asleep, or waking too early
Methamphetamine use: a comprehensive review of molecular, biochemical, and physiological effects
Berman SM, et al.
Methamphetamine - StatPearls
Richards JR, et al.
Generalized anxiety disorder or anxiety symptoms affecting daily life
Methamphetamine use: a comprehensive review of molecular, biochemical, and physiological effects
Berman SM, et al.
A review of the clinical pharmacology of methamphetamine.
Cruickshank CC, Dyer KR
Methamphetamine - StatPearls
Richards JR, et al.
Coronary artery disease or other cardiac conditions
Methamphetamine use: a comprehensive review of molecular, biochemical, and physiological effects
Berman SM, et al.
A review of the clinical pharmacology of methamphetamine.
Cruickshank CC, Dyer KR
Research (5 studies)
Methamphetamine - StatPearls
Richards JR, et al.
Methamphetamine: effects on the brain, gut and immune system
PubMed/Review authors not specified in result
Methamphetamine use: a comprehensive review of molecular, biochemical, and physiological effects
Berman SM, et al.
A review of the clinical pharmacology of methamphetamine.
Cruickshank CC, Dyer KR
Neuropsychological effects of chronic methamphetamine use on human performance
Hart CL, Marvin CB, Silver R, Smith EE
Community updates
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