N-Acetylcysteine
supplement Under reviewA derivative of the amino acid L-cysteine that acts as a precursor to glutathione, providing antioxidant, anti-inflammatory, and mucolytic support.
Research summary
Clinical research on NAC in healthy humans shows mixed but promising results. Studies demonstrate that NAC can reduce inflammatory markers including C-reactive protein and interleukin-6, lower homocysteine levels in a dose-dependent manner, and improve markers of oxidative stress. Evidence supports benefits for respiratory function, with some studies showing maintained lung function over 24 weeks compared to placebo deterioration. However, research also reveals important cautions: animal studies found that NAC supplementation in aged mice increased adenocarcinoma development in lung tissue, raising concerns about long-term safety in certain contexts. Most human clinical trials remain limited in scope, and long-term safety data in healthy populations is incomplete. Researchers recommend avoiding self-medication with NAC supplements pending results from ongoing clinical trials.
Reported Benefits
No reports yet
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N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Potential?)
Dean, O. M., Giorlando, F., Berk, M.
Clinical efficacy of N-acetylcysteine for COVID-19: A systematic review and meta-analysis of randomized controlled trials.
Not specified
N-Acetylcysteine (NAC): Impacts on Human Health.
Not specified
Effects of N-acetylcysteine on aging cell and obesity complications in obese adults: a randomized, double-blind clinical trial.
Not specified
No reports yet
Be the first to report this effect and help the community.
Add N-acetylcysteine to your stack to report effects
N-Acetylcysteine (NAC): Impacts on Human Health.
Not specified
N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Potential?)
Dean, O. M., Giorlando, F., Berk, M.
No reports yet
Be the first to report this effect and help the community.
Add N-acetylcysteine to your stack to report effects
Effects of N-acetylcysteine on aging cell and obesity complications in obese adults: a randomized, double-blind clinical trial.
Not specified
No reports yet
Be the first to report this effect and help the community.
Add N-acetylcysteine to your stack to report effects
Effects of N-acetylcysteine on aging cell and obesity complications in obese adults: a randomized, double-blind clinical trial.
Not specified
No reports yet
Be the first to report this effect and help the community.
Add N-acetylcysteine to your stack to report effects
Effects of N-acetylcysteine on aging cell and obesity complications in obese adults: a randomized, double-blind clinical trial.
Not specified
No reports yet
Be the first to report this effect and help the community.
Add N-acetylcysteine to your stack to report effects
N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Potential?)
Dean, O. M., Giorlando, F., Berk, M.
Reported Side Effects
No reports yet
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Add N-acetylcysteine to your stack to report effects
N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Potential?)
Dean, O. M., Giorlando, F., Berk, M.
No reports yet
Be the first to report this effect and help the community.
Add N-acetylcysteine to your stack to report effects
N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Potential?)
Dean, O. M., Giorlando, F., Berk, M.
No reports yet
Be the first to report this effect and help the community.
Add N-acetylcysteine to your stack to report effects
N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Potential?)
Dean, O. M., Giorlando, F., Berk, M.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Metabolic disorder characterized by high blood sugar
Effects of N-acetylcysteine on aging cell and obesity complications in obese adults: a randomized, double-blind clinical trial.
Not specified
Research (4 studies)
Effects of N-acetylcysteine on aging cell and obesity complications in obese adults: a randomized, double-blind clinical trial.
Not specified
Clinical efficacy of N-acetylcysteine for COVID-19: A systematic review and meta-analysis of randomized controlled trials.
Not specified
N-Acetylcysteine (NAC): Impacts on Human Health.
Not specified
N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Potential?)
Dean, O. M., Giorlando, F., Berk, M.
Community updates
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