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NSAIDs (Non-steroidal anti-inflammatory drugs)
medication Under reviewNSAIDs are a class of medications that reduce pain, fever, and inflammation by inhibiting the enzyme cyclooxygenase (COX), which prevents the production of prostaglandins, thromboxanes, and prostacyclins from arachidonic acid. This mechanism diminishes pain signaling, lowers the body's temperature set-point, and curbs inflammatory responses without involving steroids. Common examples include ibuprofen, naproxen, and aspirin, available over-the-counter or by prescription.
Research summary
Scientific evidence supports NSAIDs for short-term relief of pain and inflammation in healthy individuals, particularly post-exercise soreness, by blocking prostaglandin synthesis. However, consensus highlights risks with prolonged use, including gastrointestinal damage, renal impairment, and cardiovascular events, even in healthy subjects. Studies in healthy humans are limited for long-term benefits, with most data emphasizing adverse effects over sustained therapeutic gains.
Reported Benefits
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The Influence of NSAIDs on Physiologic Processes and Exercise
Physio-pedia contributors
Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population.
John G. Ryan, Yasmin Khodeir, et al.
No reports yet
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Add Nsaids (non-steroidal anti-inflammatory drugs) to your stack to report effects
The Influence of NSAIDs on Physiologic Processes and Exercise
Physio-pedia contributors
Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population.
John G. Ryan, Yasmin Khodeir, et al.
No reports yet
Be the first to report this effect and help the community.
Add Nsaids (non-steroidal anti-inflammatory drugs) to your stack to report effects
The Influence of NSAIDs on Physiologic Processes and Exercise
Physio-pedia contributors
No reports yet
Be the first to report this effect and help the community.
Add Nsaids (non-steroidal anti-inflammatory drugs) to your stack to report effects
The Influence of NSAIDs on Physiologic Processes and Exercise
Physio-pedia contributors
Reported Side Effects
No reports yet
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Peri-onset non-steroidal anti-inflammatory drugs use and organ failure in acute pancreatitis: A multicenter retrospective analysis.
Muhammad Sajid Hamid Akash, et al.
Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Selective COX-2 Inhibitors on the Small and Large Intestine
Multiple authors
Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population.
John G. Ryan, Yasmin Khodeir, et al.
No reports yet
Be the first to report this effect and help the community.
Add Nsaids (non-steroidal anti-inflammatory drugs) to your stack to report effects
Addition of antimicrobials to oral sprays containing nonsteroidal antiinflammatory drugs does not reduce the severity of postoperative sore throat: a prospective, randomized, placebo-controlled trial.
Garret A. FitzGerald
Cardiovascular Implications of Non-steroidal Anti-inflammatory Drugs: A Comprehensive Review, with Emphasis on Patients with Rheumatoid Arthritis.
Multiple authors (ECR Journal review)
Research (6 studies)
Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population.
John G. Ryan, Yasmin Khodeir, et al.
Cardiovascular Implications of Non-steroidal Anti-inflammatory Drugs: A Comprehensive Review, with Emphasis on Patients with Rheumatoid Arthritis.
Multiple authors (ECR Journal review)
The Influence of NSAIDs on Physiologic Processes and Exercise
Physio-pedia contributors
Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Selective COX-2 Inhibitors on the Small and Large Intestine
Multiple authors
Peri-onset non-steroidal anti-inflammatory drugs use and organ failure in acute pancreatitis: A multicenter retrospective analysis.
Muhammad Sajid Hamid Akash, et al.
Addition of antimicrobials to oral sprays containing nonsteroidal antiinflammatory drugs does not reduce the severity of postoperative sore throat: a prospective, randomized, placebo-controlled trial.
Garret A. FitzGerald
Community updates
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