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Paroxetine
medication Under reviewA selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat depression, anxiety, and other mental health conditions.
Research summary
Scientific evidence from randomized controlled trials and meta-analyses primarily demonstrates paroxetine's modest efficacy over placebo in reducing symptoms of anxiety and depression, with effect sizes indicating clinical benefits in responder rates and symptom score improvements. However, overall treatment acceptability is limited by higher dropout rates due to adverse events, and superiority to placebo is not consistently observed across all outcomes in acute treatment settings. Research consensus highlights its role in psychiatric applications but notes challenges with tolerability and lack of clear advantages in healthy populations without disorders.
Reported Benefits
No reports yet
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Paroxetine Clinical BPCA
FDA Review Team
The Efficacy of Paroxetine and Placebo in Treating Anxiety and Depression
Multiple authors (meta-analysis)
Effectiveness of paroxetine in the treatment of acute major depression in adults: a systematic re-examination of published and unpublished data from randomized trials.
Undurraga J, Baldessarini RJ
No reports yet
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Add Paroxetine to your stack to report effects
The Efficacy of Paroxetine and Placebo in Treating Anxiety and Depression
Multiple authors (meta-analysis)
Effectiveness of paroxetine in the treatment of acute major depression in adults: a systematic re-examination of published and unpublished data from randomized trials.
Undurraga J, Baldessarini RJ
No reports yet
Be the first to report this effect and help the community.
Add Paroxetine to your stack to report effects
Fixed Dose Study of PD 0332334 and Paroxetine for the Treatment of Social Anxiety Disorder
Not specified in record
The Efficacy of Paroxetine and Placebo in Treating Anxiety and Depression
Multiple authors (meta-analysis)
Reported Side Effects
No reports yet
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Add Paroxetine to your stack to report effects
Effectiveness of paroxetine in the treatment of acute major depression in adults: a systematic re-examination of published and unpublished data from randomized trials.
Undurraga J, Baldessarini RJ
No reports yet
Be the first to report this effect and help the community.
Add Paroxetine to your stack to report effects
Effectiveness of paroxetine in the treatment of acute major depression in adults: a systematic re-examination of published and unpublished data from randomized trials.
Undurraga J, Baldessarini RJ
No reports yet
Be the first to report this effect and help the community.
Add Paroxetine to your stack to report effects
Effectiveness of paroxetine in the treatment of acute major depression in adults: a systematic re-examination of published and unpublished data from randomized trials.
Undurraga J, Baldessarini RJ
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Major depressive disorder or persistent depressive symptoms
Effectiveness of paroxetine in the treatment of acute major depression in adults: a systematic re-examination of published and unpublished data from randomized trials.
Undurraga J, Baldessarini RJ
Paroxetine Clinical BPCA
FDA Review Team
The Efficacy of Paroxetine and Placebo in Treating Anxiety and Depression
Multiple authors (meta-analysis)
Generalized anxiety disorder or anxiety symptoms affecting daily life
Fixed Dose Study of PD 0332334 and Paroxetine for the Treatment of Social Anxiety Disorder
Not specified in record
The Efficacy of Paroxetine and Placebo in Treating Anxiety and Depression
Multiple authors (meta-analysis)
Research (4 studies)
The Efficacy of Paroxetine and Placebo in Treating Anxiety and Depression
Multiple authors (meta-analysis)
Fixed Dose Study of PD 0332334 and Paroxetine for the Treatment of Social Anxiety Disorder
Not specified in record
Effectiveness of paroxetine in the treatment of acute major depression in adults: a systematic re-examination of published and unpublished data from randomized trials.
Undurraga J, Baldessarini RJ
Paroxetine Clinical BPCA
FDA Review Team
Community updates
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