Beta
Prokinetic agents
medication Under reviewProkinetic agents are a class of drugs and related compounds that increase gastrointestinal motility, meaning they help food and liquid move through the stomach and intestines more efficiently. They do this through several mechanisms depending on the agent, including stimulation of serotonin 5-HT4 receptors, dopamine D2 receptor blockade, motilin receptor activation, or other pathways that increase coordinated smooth muscle activity. In healthy human studies, prokinetic agents have been shown to accelerate gastric emptying and/or intestinal transit, and in some cases increase stool frequency and improve stool consistency. Their broader clinical use is to treat symptoms related to delayed motility such as functional dyspepsia, slow transit constipation, gastroparesis, and other motility disorders, although the strongest evidence for benefit is generally in patients with digestive conditions rather than healthy adults.
Research summary
The healthiest-human evidence base is limited and often comes from small crossover or pharmacokinetic studies, but it consistently shows that prokinetic agents can speed gastric emptying, small-bowel transit, or colonic transit in healthy volunteers. A classic randomized crossover trial with the investigational agent R093877 found marked, consistent effects on stool frequency and transit in healthy subjects, and a small healthy-volunteer study with prucalopride showed faster gastric emptying and small-bowel transit. Most larger evidence syntheses focus on patients with functional dyspepsia or other motility disorders rather than healthy people, and those reviews generally conclude that prokinetics can improve symptoms and objective motility measures in those conditions. For healthy adults, the main documented effect is improved transit/motility rather than general health enhancement, and adverse effects depend on the specific drug class used.
Reported Benefits
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Pharmacomagnetography assessment of the prokinetic effect on gastric emptying and small bowel transit of prucalopride in healthy volunteers
Not clearly listed in the provided record
Effects of ghrelin receptor agonist, relamorelin, on gastric motor functions and satiation in healthy volunteers.
Nelson AD, Camilleri M, Acosta A, Busciglio I, Linker Nord S, Boldingh I, et al.
Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.
Not clearly listed in the provided record
No reports yet
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Add Prokinetic agents to your stack to report effects
Effects of ghrelin receptor agonist, relamorelin, on gastric motor functions and satiation in healthy volunteers.
Nelson AD, Camilleri M, Acosta A, Busciglio I, Linker Nord S, Boldingh I, et al.
Pharmacomagnetography assessment of the prokinetic effect on gastric emptying and small bowel transit of prucalopride in healthy volunteers
Not clearly listed in the provided record
Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.
Not clearly listed in the provided record
No reports yet
Be the first to report this effect and help the community.
Add Prokinetic agents to your stack to report effects
Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.
Not clearly listed in the provided record
No side effects tracked yet
No side effects have been reported by studies or users for this habit yet.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Gastroesophageal reflux disease — chronic acid reflux
Effectiveness of prokinetic agents against diseases of the digestive system
Not clearly listed in the provided record
New Developments in Prokinetic Therapy for Gastric Motility Disorders.
Review authors not clearly listed in the provided record
Irritable Bowel Syndrome — chronic gut disorder with pain, bloating, and altered bowel habits
Effects of ghrelin receptor agonist, relamorelin, on gastric motor functions and satiation in healthy volunteers.
Nelson AD, Camilleri M, Acosta A, Busciglio I, Linker Nord S, Boldingh I, et al.
New Developments in Prokinetic Therapy for Gastric Motility Disorders.
Review authors not clearly listed in the provided record
Effectiveness of prokinetic agents against diseases of the digestive system
Not clearly listed in the provided record
Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.
Not clearly listed in the provided record
Pharmacomagnetography assessment of the prokinetic effect on gastric emptying and small bowel transit of prucalopride in healthy volunteers
Not clearly listed in the provided record
General digestive problems including bloating, irregular bowel movements, and discomfort
Effects of ghrelin receptor agonist, relamorelin, on gastric motor functions and satiation in healthy volunteers.
Nelson AD, Camilleri M, Acosta A, Busciglio I, Linker Nord S, Boldingh I, et al.
New Developments in Prokinetic Therapy for Gastric Motility Disorders.
Review authors not clearly listed in the provided record
Effectiveness of prokinetic agents against diseases of the digestive system
Not clearly listed in the provided record
Pharmacomagnetography assessment of the prokinetic effect on gastric emptying and small bowel transit of prucalopride in healthy volunteers
Not clearly listed in the provided record
Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.
Not clearly listed in the provided record
Research (5 studies)
Pharmacomagnetography assessment of the prokinetic effect on gastric emptying and small bowel transit of prucalopride in healthy volunteers
Not clearly listed in the provided record
New Developments in Prokinetic Therapy for Gastric Motility Disorders.
Review authors not clearly listed in the provided record
Effects of ghrelin receptor agonist, relamorelin, on gastric motor functions and satiation in healthy volunteers.
Nelson AD, Camilleri M, Acosta A, Busciglio I, Linker Nord S, Boldingh I, et al.
Effectiveness of prokinetic agents against diseases of the digestive system
Not clearly listed in the provided record
Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.
Not clearly listed in the provided record
Community updates
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