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Risedronate
medication Under reviewA bisphosphonate medication used to treat and prevent osteoporosis by slowing bone loss.
Research summary
Clinical trials demonstrate that risedronate significantly increases bone mineral density at key sites and reduces fracture incidence in postmenopausal women. Evidence from randomized controlled trials supports its antifracture efficacy, with rapid reductions in vertebral fracture risk observed within the first year of treatment. Safety profiles are comparable to placebo, even in patients with gastrointestinal history, though bone density gains may reverse upon discontinuation. Research consensus affirms risedronate as an effective option for osteoporosis management, with consistent benefits across multiple phase III studies. Limited data exist specifically on healthy humans without osteoporosis risk, as most trials target at-risk populations, but preservation of bone mass in early postmenopausal women without prior fractures indicates broader skeletal support potential.
Reported Benefits
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Safety and efficacy of risedronate in patients with age-related reduced renal function as estimated by the Cockcroft and Gault method: a pooled analysis of nine clinical trials.
Miller PD, et al.
The efficacy and safety of denosumab, risedronate, alendronate and teriparatide to treat male osteoporosis: a systematic review and bayesian network meta-analysis.
Bochonner F, et al.
Early Changes in Biochemical Markers of Bone Resorption Predict the Reduction in Vertebral Fracture Risk during the First Year of Treatment with Risedronate
Eastell R, et al.
Risedronate Prevents New Vertebral Fractures in Postmenopausal Women with Low Bone Mass
Ettinger B, et al.
Effect of Risedronate on New Vertebral Fractures in Postmenopausal Women
Reginster JY, et al.
Reported Side Effects
No reports yet
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Add Risedronate to your stack to report effects
Safety and efficacy of risedronate in patients with age-related reduced renal function as estimated by the Cockcroft and Gault method: a pooled analysis of nine clinical trials.
Miller PD, et al.
Research (5 studies)
The efficacy and safety of denosumab, risedronate, alendronate and teriparatide to treat male osteoporosis: a systematic review and bayesian network meta-analysis.
Bochonner F, et al.
Safety and efficacy of risedronate in patients with age-related reduced renal function as estimated by the Cockcroft and Gault method: a pooled analysis of nine clinical trials.
Miller PD, et al.
Early Changes in Biochemical Markers of Bone Resorption Predict the Reduction in Vertebral Fracture Risk during the First Year of Treatment with Risedronate
Eastell R, et al.
Risedronate Prevents New Vertebral Fractures in Postmenopausal Women with Low Bone Mass
Ettinger B, et al.
Effect of Risedronate on New Vertebral Fractures in Postmenopausal Women
Reginster JY, et al.
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