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Sildenafil
medication Under reviewA phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction and pulmonary arterial hypertension.
Research summary
Scientific evidence from human studies in healthy subjects shows sildenafil produces transient, modest decreases in blood pressure and vasodilation without significant impacts on heart rate or cardiac output. It is well-tolerated, with vasodilation-related symptoms like headache being common. Limited data suggest possible enhancements in attention processing, but comprehensive consensus on cognitive or performance benefits in healthy humans remains preliminary due to sparse direct studies.
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Event-related brain potentials suggest an enhanced ability to focus attention following sildenafil administration in healthy young men
Jäkel L, et al.
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Research (1 study)
Event-related brain potentials suggest an enhanced ability to focus attention following sildenafil administration in healthy young men
Jäkel L, et al.
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