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Sodium Picosulfate
medication Under reviewA stimulant laxative used to treat constipation or to prepare the bowel for medical procedures.
Research summary
Human studies in adults show that sodium picosulfate improves stool frequency, straining, and constipation-related symptoms, with benefits demonstrated in randomized placebo-controlled and comparative trials in chronic constipation. It has also been studied for bowel preparation, where it is effective and generally well tolerated. The evidence base is focused on gastrointestinal use rather than broad health optimization. Overall, the research consensus is that sodium picosulfate is an effective stimulant laxative for constipation and bowel cleansing, but it is not a general-purpose supplement. Its main limitations are expected laxative adverse effects such as diarrhea and abdominal discomfort, and its use should be directed toward short-term bowel management rather than routine long-term supplementation.
Reported Benefits
No reports yet
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Sodium picosulfate in opioid-induced constipation: results of an open-label, prospective, dose-ranging study.
Rogers et al.
Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation.
Kamm et al.
Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation.
Mueller-Lissner et al.
Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial.
Guglielmetti S, et al.
No reports yet
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Add Sodium picosulfate to your stack to report effects
Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation.
Kamm et al.
Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial.
Guglielmetti S, et al.
Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation.
Mueller-Lissner et al.
No reports yet
Be the first to report this effect and help the community.
Add Sodium picosulfate to your stack to report effects
Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial.
Guglielmetti S, et al.
Reported Side Effects
No reports yet
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Add Sodium picosulfate to your stack to report effects
Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial.
Guglielmetti S, et al.
No reports yet
Be the first to report this effect and help the community.
Add Sodium picosulfate to your stack to report effects
Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation.
Kamm et al.
No reports yet
Be the first to report this effect and help the community.
Add Sodium picosulfate to your stack to report effects
Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial.
Guglielmetti S, et al.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Irritable Bowel Syndrome — chronic gut disorder with pain, bloating, and altered bowel habits
Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation.
Mueller-Lissner et al.
General digestive problems including bloating, irregular bowel movements, and discomfort
Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation.
Mueller-Lissner et al.
Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial.
Guglielmetti S, et al.
Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation.
Kamm et al.
Sodium picosulfate in opioid-induced constipation: results of an open-label, prospective, dose-ranging study.
Rogers et al.
Research (4 studies)
Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation.
Mueller-Lissner et al.
Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial.
Guglielmetti S, et al.
Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation.
Kamm et al.
Sodium picosulfate in opioid-induced constipation: results of an open-label, prospective, dose-ranging study.
Rogers et al.
Community updates
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