Spermidine

A randomized controlled trial in older adults aged 60-80 reported improved memory performance and mnemonic discrimination after three months of 1.2 mg daily spermidine supplementation, with follow-up confirming sustained cognitive benefits and no adverse effects.

Phase II randomized, double-blind, placebo-controlled trial showed daily 1.2 mg spermidine supplementation for three months improved cognitive function in older adults with subjective cognitive decline, with high compliance and no changes in vital signs or blood parameters.

A randomized controlled trial in older adults aged 60-80 reported improved memory performance and mnemonic discrimination after three months of 1.2 mg daily spermidine supplementation, with follow-up confirming sustained cognitive benefits and no adverse effects.

Phase II randomized, double-blind, placebo-controlled trial showed daily 1.2 mg spermidine supplementation for three months improved cognitive function in older adults with subjective cognitive decline, with high compliance and no changes in vital signs or blood parameters.

Two prospective population-based studies using food questionnaires showed higher nutritional spermidine uptake independently associated with reduced overall, cardiovascular, and cancer-related mortality in humans after adjusting for confounders.

Epidemiological studies correlate elevated dietary polyamine uptake, including spermidine, with reduced cardiovascular and cancer-related mortality in humans.

Two prospective population-based studies using food questionnaires showed higher nutritional spermidine uptake independently associated with reduced overall, cardiovascular, and cancer-related mortality in humans after adjusting for confounders.

Epidemiological studies correlate elevated dietary polyamine uptake, including spermidine, with reduced cardiovascular and cancer-related mortality in humans.