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Tiludronate
medication Under reviewA bisphosphonate medication used to treat Paget's disease of bone by inhibiting osteoclast-mediated bone resorption.
Research summary
Scientific evidence for tiludronate centers on its efficacy in reducing markers of bone resorption and pain in Paget's disease of bone, with randomized controlled trials showing significant normalization of serum alkaline phosphatase levels in a substantial proportion of patients. No studies were identified involving healthy human subjects, limiting direct applicability to general supplementation in unaffected individuals. Consensus supports its safety and tolerability in treated populations, with pharmacokinetics well-characterized in both healthy volunteers and patients.
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