Beta
Tolazamide
medication Under reviewA sulfonylurea medication used to help control blood sugar levels in patients with type 2 diabetes.
Research summary
Clinical research on tolazamide consists primarily of intervention studies in adults with type 2 diabetes, including randomized comparisons with other sulfonylureas and with exogenous insulin. These trials consistently show that tolazamide effectively lowers fasting blood glucose and glycosylated hemoglobin and can provide glycemic control comparable to that achieved with insulin in appropriately selected patients with residual beta-cell function. Other work indicates that improved glycemic control with tolazamide therapy is associated with normalization of whole-body glucose utilization toward nondiabetic levels in people with type 2 diabetes. The evidence base focuses on disease treatment rather than enhancement of health in otherwise healthy individuals. There are no controlled trials using tolazamide as a metabolic aid in healthy humans, and all efficacy data relate to patients with type 2 diabetes or related dysglycemia. Safety data from clinical use and prescribing information highlight hypoglycemia as the primary risk, along with infrequent dermatologic or gastrointestinal adverse effects. In contemporary guidelines, tolazamide is considered an older agent and is generally not used for wellness or performance purposes in healthy populations.
Reported Benefits
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CLINICAL STUDIES OF TOLAZAMIDE AND TOLBUTAMIDE: COMPARATIVE EFFECTIVENESS OF CONTROL OF DIABETES MELLITUS.
Himsworth RL, Carrington SP
A comparison of the effects of tolazamide and tolbutamide upon blood glucose, serum insulin, cholesterol and triglycerides in maturity-onset diabetes
Samaan N, Fraser R
Tolazamide prescribing information (clinical safety and efficacy data)
U.S. Food and Drug Administration
No reports yet
Be the first to report this effect and help the community.
Add Tolazamide to your stack to report effects
A comparison of the effects of tolazamide and tolbutamide upon blood glucose, serum insulin, cholesterol and triglycerides in maturity-onset diabetes
Samaan N, Fraser R
Tolazamide prescribing information (clinical safety and efficacy data)
U.S. Food and Drug Administration
No side effects tracked yet
No side effects have been reported by studies or users for this habit yet.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Metabolic disorder characterized by high blood sugar and insulin resistance
CLINICAL STUDIES OF TOLAZAMIDE AND TOLBUTAMIDE: COMPARATIVE EFFECTIVENESS OF CONTROL OF DIABETES MELLITUS.
Himsworth RL, Carrington SP
A comparison of the effects of tolazamide and tolbutamide upon blood glucose, serum insulin, cholesterol and triglycerides in maturity-onset diabetes
Samaan N, Fraser R
Tolazamide prescribing information (clinical safety and efficacy data)
U.S. Food and Drug Administration
Research (3 studies)
Tolazamide prescribing information (clinical safety and efficacy data)
U.S. Food and Drug Administration
A comparison of the effects of tolazamide and tolbutamide upon blood glucose, serum insulin, cholesterol and triglycerides in maturity-onset diabetes
Samaan N, Fraser R
CLINICAL STUDIES OF TOLAZAMIDE AND TOLBUTAMIDE: COMPARATIVE EFFECTIVENESS OF CONTROL OF DIABETES MELLITUS.
Himsworth RL, Carrington SP
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