Beta
Tolbutamide
medication Under reviewA first-generation sulfonylurea medication that stimulates insulin release from pancreatic beta cells to manage type 2 diabetes.
Research summary
The human evidence base for tolbutamide in healthy subjects is limited and mostly mechanistic. Studies in normal volunteers show that tolbutamide can rapidly stimulate insulin secretion and produce hypoglycemia, and that the magnitude of these effects varies substantially between individuals, partly because of differences in drug metabolism. Research in healthy adults also shows that tolbutamide metabolism is genetically variable and that its effects can be influenced by interactions with other drugs that share metabolic pathways. Overall, tolbutamide is not supported as a health supplement for healthy people. The human literature mainly supports its use as a glucose-lowering pharmacologic agent and as an experimental probe for insulin and glucagon physiology rather than for broad health benefits.
Reported Benefits
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The use of tolbutamide-induced hypoglycemia to examine the intraislet role of insulin in mediating glucagon release in normal humans.
Not fully listed in search results
Population-based modeling to demonstrate extrapancreatic effects of tolbutamide.
Not fully listed in search results
The significance of the blood glucose level for plasma insulin response to intravenously administered tolbutamide in healthy subjects
Cerasi E, Chowers I, Luft R, et al.
No reports yet
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The significance of the blood glucose level for plasma insulin response to intravenously administered tolbutamide in healthy subjects
Cerasi E, Chowers I, Luft R, et al.
The use of tolbutamide-induced hypoglycemia to examine the intraislet role of insulin in mediating glucagon release in normal humans.
Not fully listed in search results
Population-based modeling to demonstrate extrapancreatic effects of tolbutamide.
Not fully listed in search results
No reports yet
Be the first to report this effect and help the community.
Add Tolbutamide to your stack to report effects
The use of tolbutamide-induced hypoglycemia to examine the intraislet role of insulin in mediating glucagon release in normal humans.
Not fully listed in search results
Reported Side Effects
No reports yet
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Add Tolbutamide to your stack to report effects
The significance of the blood glucose level for plasma insulin response to intravenously administered tolbutamide in healthy subjects
Cerasi E, Chowers I, Luft R, et al.
No reports yet
Be the first to report this effect and help the community.
Add Tolbutamide to your stack to report effects
The significance of the blood glucose level for plasma insulin response to intravenously administered tolbutamide in healthy subjects
Cerasi E, Chowers I, Luft R, et al.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Metabolic disorder characterized by high blood sugar and insulin resistance
The significance of the blood glucose level for plasma insulin response to intravenously administered tolbutamide in healthy subjects
Cerasi E, Chowers I, Luft R, et al.
Population-based modeling to demonstrate extrapancreatic effects of tolbutamide.
Not fully listed in search results
Failure of induction of liver microsomal enzymes by tolbutamide in maturity-onset diabetics.
Unknown
Research (4 studies)
Population-based modeling to demonstrate extrapancreatic effects of tolbutamide.
Not fully listed in search results
The use of tolbutamide-induced hypoglycemia to examine the intraislet role of insulin in mediating glucagon release in normal humans.
Not fully listed in search results
Failure of induction of liver microsomal enzymes by tolbutamide in maturity-onset diabetics.
Unknown
The significance of the blood glucose level for plasma insulin response to intravenously administered tolbutamide in healthy subjects
Cerasi E, Chowers I, Luft R, et al.
Community updates
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