Beta
Tranylcypromine
medication Under reviewA nonselective, irreversible monoamine oxidase inhibitor (MAOI) used primarily as an antidepressant.
Research summary
In healthy human volunteers, tranylcypromine demonstrates dose-dependent MAO inhibition, confirmed by increased urinary tryptamine excretion and heightened pressor sensitivity to tyramine and norepinephrine. Research in healthy subjects is limited primarily to pharmacokinetic and pharmacodynamic assessments, showing reliable onset, extent, and duration of enzyme inhibition without extensive exploration of broader health benefits.
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