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Venlafaxine
medication Under reviewA serotonin-norepinephrine reuptake inhibitor (SNRI) commonly used to treat depression and anxiety disorders.
Research summary
Scientific evidence on venlafaxine in healthy human subjects is sparse, with most research focused on its neuroendocrine effects rather than broad health benefits. A single key study in healthy males showed dose-dependent increases in prolactin and growth hormone without significant cortisol changes, indicating selective hormonal modulation. Overall consensus highlights its pharmacological action on monoamines but lacks robust data on benefits for healthy adults, as trials predominantly involve patients with conditions like depression. Adverse effects are better documented, with higher rates of non-serious events like sexual dysfunction and anorexia in comparative analyses, though these derive from patient populations. No strong evidence supports routine use in healthy humans, and growth impacts observed in pediatric studies raise caution for long-term application.
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20-699, SE5-030: Effexor (venlafaxine HCl) Tablets - FDA Clinical BPCA Review
FDA Review Team
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Major depressive disorder or persistent depressive symptoms
20-699, SE5-030: Effexor (venlafaxine HCl) Tablets - FDA Clinical BPCA Review
FDA Review Team
The risks of adverse events with venlafaxine for adults with major depressive disorder: a systematic review with trial sequential analysis and network meta-analysis
Kahlert J, et al.
Research (2 studies)
The risks of adverse events with venlafaxine for adults with major depressive disorder: a systematic review with trial sequential analysis and network meta-analysis
Kahlert J, et al.
20-699, SE5-030: Effexor (venlafaxine HCl) Tablets - FDA Clinical BPCA Review
FDA Review Team
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